The Federation of American Societies for Experimental Biology reports that gum disease causing bacteria—Porphyromonas gingivalis—manipulate the immune system to be able to thrive in the gums. The results of a research published recently in the Journal of Leukocyte Biology shows how the bacteria prompt the production of Interleukin-10 (IL-10), an anti-inflammatory molecule which inhibits T-cells that would otherwise destroy gingivitis bacteria from taking a hold in the mouth.
According to Dr. Jannet Katz, a dentist and researcher at the Department of Pediatric Dentistry at the University of Alabama in Birmingham, more than half of the Americans who are over 50 years-of-age get adult periodontal disease. “We hope that the results of our study will ultimately help in the development of novel treatments that could prevent or ameliorate the chronic infection caused by the pathogen P. gingivalis,” says Katz.
In addition to highlighting the mechanism P. gingivalis bacteria uses to establish a chronic infection, and how the disease develops, it also demonstrates why early detection and treatment is important for prevention and eradication of gum disease bacteria from the mouth.
"Gum diseases and the infections that cause them can be incredibly stubborn and difficult to treat," says John Wherry, Deputy Editor of the Journal of Leukocyte Biology. According to Wherry, "What isn't as well known is why these infections are so difficult to eradicate. These new studies now demonstrate that these bacteria go beyond merely evading our body's defenses and actually manipulate our immune systems for their own survival."
Gum disease is a very common disease according to the Centers for Disease Control and Prevention (CDC). But it is preventable to a large degree and if detected and treated early, can be cured with ease. Routine oral care of brushing and flossing, together with a visit to a dentist every six months would help you be safe from developing gum disease.
You can read more about gum disease causes, prevention and treatments in the FreeDentistFinder.com article archive.
Visit FreeDentistFinder.com and search for a local dentist if you need a routine dental checkup or treatment for gum disease. You can search by a zip code and dental specialty.
Dalia E. Gaddis, Craig L. Maynard, Casey T. Weaver, Suzanne M. Michalek, and Jannet Katz. Role of TLR2-dependent IL-10 production in the inhibition of the initial IFN-γ T cell response to J. Leukoc. Biol. January 2013 93:21-31; doi:10.1189/jlb.0512220 http://www.jleukbio.org/content/93/1/21.abstract